Question Board
 Anonymous November 29, 2023 |
Studies on H. pylori Outer Membrane VesiclesH. pylori OMVs contain lipopolysaccharides, phosphatidylglycerol, proteins, DNA, and RNA. These components influence its ability to cause disease. For example, the OMVs contain H. pylori virulence proteins, which have a destructive effect on gastric cells. Some proteins and RNA in the OMVs elicit immune responses. What’s more, H. pylori OMVs can also promote biofilm formation, which protects H. pylori. Overall, there is a need for an in-depth study of H. pylori OMVs.
Effect of environmental and genetic factors on the number and size of OMVs The number and size of H. pylori OMVs have been found to be related to environmental factors and their genetic profile. We provide services on the effect of different culture additives or other substances (including drugs) on the production of OMVs. We also provide gene (e.g., HP1126) knockout and overexpression services to help explore the number and size of OMVs. Protein analysis and identification We can analyze and identify the proteins of the OMVs from different growth stages or different strains. We provide analysis to help find protein differences of the OMVs produced by different growth stages or different strains and we help to investigate the factors of protein differences. Structure and function studies of the component of H. pylori OMVs We provide explorations of the functions of unknown proteins, DNAs, and RNAs found in the OMVs of H. pylori. We offer in vitro cellular experiments to explore the effects of the component on the growth, apoptosis, and function of gastric cells. We also offer in vitro animal experiments to explore the immune response and physiological responses induced by the component. For the unknown proteins involved, we also provide structural analysis. Effect of environmental and genetic factors on the number and size of OMVs The number and size of H. pylori OMVs have been found to be related to environmental factors and their genetic profile. We provide services on the effect of different culture additives or other substances (including drugs) on the production of OMVs. We also provide gene (e.g., HP1126) knockout and overexpression services to help explore the number and size of OMVs. Protein analysis and identification We can analyze and identify the proteins of the OMVs from different growth stages or different strains. We provide analysis to help find protein differences of the OMVs produced by different growth stages or different strains and we help to investigate the factors of protein differences. Structure and function studies of the component of H. pylori OMVs We provide explorations of the functions of unknown proteins, DNAs, and RNAs found in the OMVs of H. pylori. We offer in vitro cellular experiments to explore the effects of the component on the growth, apoptosis, and function of gastric cells. We also offer in vitro animal experiments to explore the immune response and physiological responses induced by the component. For the unknown proteins involved, we also provide structural analysis. Category: General |
