Iron Metabolism-related Gene Knock-in Service

Iron metabolism gene knock-in cell

Iron is widely distributed in the body and clinical and experimental studies have shown that disturbances in iron metabolism in the central nervous system are associated with a number of neuropathies, such as Alzheimer's disease (AD) and Parkinson's disease (PD), but the exact mechanisms involved are not yet clear. Knock-in/knock-out of genes related to iron metabolism is often used to study the mechanisms involved in their association with disease.

LRRK2
Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant Parkinson's disease (PD), and common genetic variants identified through genome-wide association studies are associated with idiopathic PD and inflammatory diseases. Research show that G2019S LRRK2 knock-in mice exhibit increased iron accumulation within microglia in the striatum in response to neuroinflammation compared to WT controls. These data support a role of LRRK2 in modulating normal iron uptake and storage in response to proinflammatory stimuli in microglia.

Category: General