Gene Therapy Development Service for T1DM

Genetics of T1DM

The highly polymorphic HLA region on chromosome 6p21 encodes for glycoproteins belonging to the major histocompatibility complex (MHC). These molecules interact with peptide antigens, allowing the immune cells to recognize foreign antigens and trigger an immune response. Two HLA class II haplotypes involved in antigen presentation is HLA-DR and HLA-DQ.

Gene Therapy for Diabetes

The research on gene therapy for diabetes is mainly aimed at T1DM, T2DM and diabetes complications. Through the research on relevant target genes and targets and the carrier of gene targeted therapy for diabetes, a series of research and exploration have been carried out.

In T1DM, insulin secreting β-cells are destroyed by inflammatory cells, so gene therapy for T1DM is based on β-cells were the best target. At present, the methods of target gene transfer used in gene therapy can be divided into two categories.

Category: General