Question Board
 Anonymous November 7, 2023 |
Thermodynamic Characterization of Biomolecular InteractionsThermodynamic Characterization of Biomolecular Interactions In the field of drug discovery, the term "thermodynamics" refers to the study of the thermal changes that occur when molecules interact with each other. Thermodynamic characterization of such temperature changes plays an important role in the drug design and development process. With the continuous development of our understanding of the energy basis of molecular interaction, thermodynamic characterization methods have also made significant progress, accelerating the thermodynamic driven drug design. Comprehensive thermodynamic characterization can provide information on the energy balance driving binding interactions, which is essential for accelerating drug development to achieve optimal energy interaction profiles while maintaining good pharmacological properties. ITC is currently one of the most commonly used techniques for the quantitative study of various biomolecular interactions. The general applicability of ITC and the exceptionally low error in affinity measurements commonly observed with this technique make it the gold standard for measuring binding parameters. Category: General |
