A bone marrow transplant (BMT) is a procedure that replaces unhealthy bone marrow with healthy stem cells. It's used to treat certain cancers, blood disorders, and autoimmune diseases. It's possible, but less likely, for a cousin to be a bone marrow match for a BMT transplant compared to closer relatives like siblings.
HLA (Human Leukocyte Antigen) proteins are crucial for immune system function and transplant compatibility. Cousins share a smaller portion of their HLA genes compared to siblings or parents. A perfect match across all HLA genes is ideal, but not always necessary.
Partial matches or mismatches can sometimes be successful, especially with advancements in transplant techniques.
Haploidentical Transplants utilize a half-matched donor, meaning they share only half of their HLA genes. Cousins might be considered for haploidentical transplants if they have a partial match. These transplants carry a higher risk of complications like Graft-versus-Host Disease (GVHD), where the donor's immune system attacks the recipient's body.
Extensive testing is required to determine HLA compatibility between a cousin and the recipient.
This includes blood tests and tissue typing. The bone marrow transplant team will carefully weigh the risks and benefits of using a cousin as a donor, considering factors like the patient's health, the degree of HLA match, and the availability of other potential donors.
If no suitable family match is found, the search expands to unrelated donors registered in national and international registries. Ongoing research and advancements in transplant techniques are constantly improving outcomes, even with less-than-perfect matches.
The decision of whether or not to proceed with a bone marrow transplant from a cousin is complex and should only be made in consultation with a qualified medical team specializing in transplant medicine.
For more information visit the official site:: https://www.edhacare.com/treatments/organ-transplant/bone-marrow